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Key Documents

161M-1

Sigma-Aldrich

CD61 (2f2) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

2f2, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (161M-14)
vial of 0.5 mL concentrate (161M-15)
bottle of 1.0 mL predilute (161M-17)
vial of 1.0 mL concentrate (161M-16)
bottle of 7.0 mL predilute (161M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG1

control

bone marrow

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ITGB3(3690)

General description

CD61 also known as integrin beta chain beta 3 (ITGB3) is an integrin cell-surface protein associated with cellular adhesion and cell-surface mediated signaling. Immunohistochemical staining for CD61 can be useful in evaluating normal and abnormal megakaryocytes, which can aid in the identification of some hematopoietic malignancies. Anti-CD61 reactivity is also seen in platelets, osteoclasts, and macrophages.

Quality


IVD
IVD
IVD
RUO

Linkage

CD61 Positive Control Slides, Product No. 161S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Thiele et al.
Virchows Archiv. B, Cell pathology including molecular pathology, 58(4), 295-302 (1990-01-01)
To determine the number of megakaryocyte precursors (pro- and megakaryoblasts), an immunomorphometric study was performed on paraffin-embedded trephine biopsies of the bone marrow using a monoclonal antibody against platelet glycoprotein IIIa. Eighteen control specimens from patients with no evidence of
S B Fox et al.
Histopathology, 17(1), 69-74 (1990-07-01)
Megakaryocytes in 63 bone marrow trephine biopsies were examined for their staining characteristics, location and size distribution using the monoclonal antibody Y2/51 directed against platelet glycoprotein IIIa (CD61). Megakaryocytes in normal bone marrow were evenly distributed and demonstrated homogeneous staining
A Duperray et al.
Blood, 74(5), 1603-1611 (1989-10-01)
The platelet membrane glycoproteins GPIIb and GPIIIa form a calcium-dependent heterodimer that functions as a receptor for adhesive proteins on stimulated platelets. In this study, we have investigated the kinetics of the assembly reaction that result in GPIIb-IIIa dimerization. Pulse-chase
J Thiele et al.
Analytical and quantitative cytology and histology, 12(4), 285-289 (1990-08-01)
On routinely processed trephine biopsies of the normal human bone marrow derived from 15 patients, immunostaining with a monoclonal antibody against platelet glycoprotein IIIa (Y2/51) and morphometric measurements were performed for the determination of megakaryocyte precursor cells. Based on cell
B I Goldman et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 14(6), 589-594 (2001-06-15)
Extramedullary hematopoiesis occurring in the myocardium has previously only been reported in a single case of a neonate with cyanotic congenital heart disease. Herein we report the incidental discovery of extramedullary hematopoiesis or pure erythropoiesis in four failing adult hearts
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