444286-M

MMP-2 Inhibitor II

The MMP-2 Inhibitor II, also referenced under CAS 869577-51-5, controls the biological activity of MMP-2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): MMP-2 Inhibitor II, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methyloxirane
• Empirical Formula (Hill Notation): C₁₆H₁₇NO₆S₂
• CAS Number: 869577-51-5
• Molecular Weight: 383.44
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: solid
• potency: 2.4 μM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: white
• solubility: DMSO: 200 mg/mL
• storage temp.: −20°C
• InChI: 1S/C16H17NO6S2/c1-24(18,19)17-12-2-4-13(5-3-12)23-14-6-8-16(9-7-14)25(20,21)11-15-10-22-15/h2-9,15,17H,10-11H2,1H3
• InChI key: ADEXXMLIERNFQB-UHFFFAOYSA-N

Description

General description

An oxirane analog of SB-3CT, pMS (Cat. No. 444285) that acts as a selective, active site-binding, irreversible inhibitor of MMP-2 (K_i = 2.4 µM). Although less potent, it exhibits enhanced selectivity towards MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively) than SB-3CT, pMS.

Biochem/physiol Actions

Secondary Target
MMP-2 (K_i = 45 and 379 µM for MMP-1 and MMP-7, respectively)

Warning

Toxicity: Standard Handling (A)

Other Notes

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable