This product can be solubilized at 50 mg/ml of 1M ammonium hydroxide. This product can also be
solubilized in water at 2mg/ml forming a clear to slightly hazy colorless solution. Solubility may be increased to at least 10mg/ml by solubilizing in either dilute acid or base. It is probably preferable to prepare a slightly acidic solution since this would maintain the amine group as a quaternary amine, which is less prone to oxidation. These solutions may be stored short term in the refrigerator or long term as frozen aliquots. Specifics around in vivo and/or in vitro applications have not been determined for this product. Consult the scientific literature for further information around the use of this product in these applications. You can find "Peer Reviewed Papers" near the bottom of this product's webpage for help in your search for more information.
M0253
L-Mimosine from Koa hoale seeds
≥98%
Synonym(s):
(S)-α-Amino-β-[1-(3-hydroxy-4-oxopyridine)]propionic acid, Leucenol
Sign Into View Organizational & Contract Pricing
All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C8H10N2O4
CAS Number:
Molecular Weight:
198.18
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
Quality Level
Assay
≥98%
SMILES string
N[C@@H](CN1C=CC(=O)C(O)=C1)C(O)=O
InChI
1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
InChI key
WZNJWVWKTVETCG-YFKPBYRVSA-N
General description
L-mimosine [β-N (3-hydroxy-4-pyridone)-α-amino propionic acid] is a non-protein amino acid and is a vital component of tropical legumes, such as Leucaena glauca and other legumes belonging to Mimosa spp. Structurally L-mimosine resembles dihydroxyphenylalanine except 3,4-dihydroxy-phenyl ring replaced by 3-hydroxy-4-pyridone ring.[1]
Application
L-Mimosine from Koa hoale seeds has been used to study its anti-inflammatory effect in chronic inflammatory response (potassium permanganate - induced chronic granuloma).[2]
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase.[3] It is an iron chelator that inhibits DNA replication in mammalian cells.[4] L-Mimosine has been shown to promote apoptosis in xenotransplanted human pancreatic cancer.[5] L-Mimosine stabilizes hypoxia inducible factor 1 (HIF-1) and stimulates the expression of B-cell translocation gene 2 (Btg2) and N-myc downstream regulated gene 1 (Ndrg1) at the transcriptional level, which reduce cell proliferation of prostate carcinoma cells in vitro. L-Mimosine stabilizes HIF-1 through the inhibition of prolyl hydroxylases (PHDs) which target HIF-1 through degradation.[3] The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. Mimosine inhibits cell cycle progression via iron chelation in MDA-MB-453 human breast cancer cells.[6] Mimosine, hinder folate metabolism in cell-specific manner.[4]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Li-Chuan Chung et al.
American journal of physiology. Cell physiology, 302(4), C676-C685 (2011-11-26)
L-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. B-cell translocation gene 2 (Btg2) regulates the G1/S transition phases of the cell cycle. N-myc downstream regulated gene 1 (Ndrg1) is a
Tian-Xia Jiang et al.
Theranostics, 11(3), 1458-1472 (2021-01-05)
The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related disorders, are usually associated with alterations of histone marks. Whether and how the proteasome is responsible for maintaining the histone marks during transcription and aging remain
Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells.
Kulp KS and Vulliet PR.
Toxicology and Applied Pharmacology, 139(2), 356-364 (1996)
Mimosine, a plant-derived amino acid induces apoptosis in human pancreatic cancer xenografts.
Zalatnai A and Bocsi J.
Anticancer Research, 23(5A), 4007-4009 (2003)
H Agis et al.
Journal of periodontal research, 47(2), 165-173 (2011-10-01)
Pharmacological inhibitors of prolyl hydroxylases (PHDs) can induce a proangiogenic response that favors wound healing and bone regeneration. However, the response of periodontal cells to PHD inhibitors is unknown. To determine the effects of PHD inhibitors on periodontal cells, we
-
Dear Sigma, We would like to know what solvent can be used to dissolve M0253 L-Mimosine into solution? What working concentrations are recommended to use in vivo and in cells respectively? What maximal concentrations have been used without toxicity ?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
