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Key Documents

A2562

Sigma-Aldrich

Angiotensinogen from human plasma

≥80% (SDS-PAGE)

Synonym(s):

Hypertensinogen, Renin substrate

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.26

product name

Angiotensinogen from human plasma, ≥80% (SDS-PAGE), lyophilized powder

Quality Level

Assay

≥80% (SDS-PAGE)

form

lyophilized powder

color

white

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... AGT(183)

Biochem/physiol Actions

Angiotensinogen (renin substrate), a component of the rennin-angiotensin system, is a precursor protein to a family of blood pressure and hormone release regulating peptides known as the angiotensins.

Packaging

Package size based on protein content.

Physical form

Lyophilized powder containing sodium phosphate buffer, pH 7.

Analysis Note

Protein determined by A1%/280

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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In angiotensin II (ANG II) infusion hypertension, there is an augmentation of intratubular angiotensinogen (AGT) and ANG II leading to increased urinary AGT and ANG II excretion rates associated with tissue injury. However, the changes in urinary AGT and ANG
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Biochemical, physiological and functional studies suggest that the brain renin-angiotensin system (RAS) is regulated independently of the peripheral RAS. Also, all enzymes and peptides necessary for the biosynthesis of various angiotensins have been recognized within the central nervous system. There
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Recent interest focuses on urinary renin and angiotensinogen as markers of renal renin-angiotensin system activity. Before concluding that these components are independent markers, we need to exclude that their presence in urine, like that of albumin (a protein of comparable

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