- Interaction of S-methyl methanethiosulfonate with DPPC bilayer.
Interaction of S-methyl methanethiosulfonate with DPPC bilayer.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2012-07-27)
María E Defonsi Lestard, Sonia B Díaz, María E Tuttolomondo, Santiago Sánchez Cortez, Marcelo Puiatti, Adriana B Pierini, Aida Ben Altabef
PMID22832011
ABSTRACT
The present study is a first step towards the investigation of S-methyl methanethiosulfonate (MMTS) interaction with membrane model systems like liposomes. In this paper, the interaction of MMTS with dipalmitoylphosphatidylcholine (DPPC) bilayers was studied by FTIR and SERS spectroscopy. Lysolipid effect on vesicle stability was studied. The results show that MMTS interacts to different extents with the phosphate and carbonyl groups of membranes in the gel and the liquid crystalline states. To gain a deeper insight into MMTS properties that may be potentially helpful in the design of new drugs with therapeutic effects, we performed theoretical studies that may be the basis for the design of their mode of action.