K3628
Kininogen, low molecular weight from human plasma
≥95% (SDS-PAGE), lyophilized powder
Synonym(s):
LMW kininogen
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
biological source
human plasma
Quality Level
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
64000 Da
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... KNG1 (includes EG:3827)
Application
Kininogen, low molecular weight from human plasma has been used to study rMASP-1 (recombinant mannose-binding lectin-associated serine protease 1)-mediated cleavage of LK (low molecular weight kininogen). It has been used as a standard for protein identification in milk-proteomics study.
Biochem/physiol Actions
LMW kininogen is a major extracellular cysteine proteinase inhibitor. Tissue kallikrein releases bradykinin, a potent bronchoconstrictor and vasoactive agent, from both HMW and LMY kininogen.
Physical form
Lyophilized from a solution in sodium acetate and sodium chloride.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Delphine Vincent et al.
Frontiers in genetics, 6, 360-360 (2016-01-23)
Milk is a complex fluid whose proteome displays a diverse set of proteins of high abundance such as caseins and medium to low abundance whey proteins such as ß-lactoglobulin, lactoferrin, immunoglobulins, glycoproteins, peptide hormones, and enzymes. A sample preparation method
József Dobó et al.
PloS one, 6(5), e20036-e20036 (2011-06-01)
Bradykinin (BK), generated from high-molecular-weight kininogen (HK) is the major mediator of swelling attacks in hereditary angioedema (HAE), a disease associated with C1-inhibitor deficiency. Plasma kallikrein, activated by factor XIIa, is responsible for most of HK cleavage. However other proteases
Xavier Charest-Morin et al.
Pharmacology research & perspectives, 3(2), e00119-e00119 (2015-06-04)
Tissue kallikrein (KLK-1), a serine protease, initiates the release of bradykinin (BK)-related peptides from low-molecular weight kininogen. KLK-1 and the BK B2 receptor (B2R) mediate beneficial effects on the progression of type 2 diabetes and renal disease, but the precise
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service