830843P

10:0 PA

1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt), powder

• Synonym(s): PA(10:0/10:0)
• Empirical Formula (Hill Notation): C₂₃H₄₄O₈PNa
• CAS Number: 321883-64-1
• Molecular Weight: 502.55
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 25 mg (830843P-25mg); pkg of 1 × 500 mg (830843P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 830843P
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [H][C@@](COP([O-])(O)=O)(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O.[Na+]
• InChI: 1S/C23H45O8P.Na/c1-3-5-7-9-11-13-15-17-22(24)29-19-21(20-30-32(26,27)28)31-23(25)18-16-14-12-10-8-6-4-2;/h21H,3-20H2,1-2H3,(H2,26,27,28);/q;+1/p-1/t21-;/m1./s1
• InChI key: YVHWEENUNNUSBE-ZMBIFBSDSA-M

Description

General description

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

Application

10:0 PA may be used:

• as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission
• to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to activate protein kinase C (PKC)
• as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

Biochem/physiol Actions

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

Packaging

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)

5 mL Clear Glass Sealed Ampule (830843P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids