Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

SRP3017

Sigma-Aldrich

BMP-6 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

Sinónimos:

VGR

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

potency

0.03-0.06 μg/mL ED50

mol wt

26.2 kDa

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BMP6(654)

General description

BMP6 (bone morphogenetic protein 6) is one of the BMPs which are secreted signaling proteins belonging to the transforming growth factor-β (TGF-β) superfamily. This gene is localized to human chromosome 6p24.1.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.

Biochem/physiol Actions

BMPs (bone morphogenetic proteins) were initially identified from demineralized bone extracts capable of stimulating endochondral osteogenesis at extraskeletal sites in vivo. BMP6 is thought to be involved in early embryogenesis. In hepatocellular carcinoma (HCC) the expression of this protein is suppressed due to hypermethylation, and this is linked with poor patient outcomes. This protein is also down-regulated due to CpG island methylation in CRC (colorectal carcinoma), although it is not yet been found to be linked with tumor progression or prognosis. BMP6 is involved in chondrocyte differentiation, and in fetal kidney and urinary system development. It is thought to be involved in ovulation, where it elevates the accumulation of neutrophils in ovulatory follicles and reduces the influence of protease inhibitors.

Sequence

VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH

Physical form

Lyophilized from 10 mM Tris, pH 9.0.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Expression of BMP6 is associated with its methylation status in colorectal cancer tissue but lacks prognostic significance.
Sangplod P et al
Asian Pacific Journal of Cancer Prevention, 15(17), 7091-7095 (2014)
Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma.
He Y et al
PLoS ONE, 9(1), e87994-e87994 (2014)
Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia.
Sebastiani P et al
Nature Genetics, 37(4), 435-440 (2005)
The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.
Akiyama I et al
Reproductive Sciences, 21(6), 772-777 (2014)
S M Lens et al.
Seminars in immunology, 10(6), 491-499 (1998-11-25)
In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors, whereas for the

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico