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S4701

Sigma-Aldrich

Suplatast tosylate

≥98% (HPLC)

Sinónimos:

(+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate, IPD-1151T, ST

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About This Item

Fórmula empírica (notación de Hill):
C16H26SNO4 · C7H7SO3
Número de CAS:
94055-76-2
Peso molecular:
499.64
MDL number:
MFCD00867604
UNSPSC Code:
12352200
PubChem Substance ID:
329824551
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CCOCC(O)COc2ccc(NC(=O)CC[S+](C)C)cc2

InChI

1S/C16H25NO4S.C7H8O3S/c1-4-20-11-14(18)12-21-15-7-5-13(6-8-15)17-16(19)9-10-22(2)3;1-6-2-4-7(5-3-6)11(8,9)10/h5-8,14,18H,4,9-12H2,1-3H3;2-5H,1H3,(H,8,9,10)

InChI key

RYVJQEZJUFRANT-UHFFFAOYSA-N

Application

Suplatast tosylate may be used in immune-signaling studies.

Biochem/physiol Actions

Suplatast tosylate is a dimethylsulfonium compound downregulates the expression of histamine H1 receptor gene, suppresses the activity of histidine decarboxylase and regulates IL-4 mRNA. It inhibits the release of histamines and regulates the production of IgE.1,2 Suplatast tosylate is effective in the treatment of mild-to-moderate persistent asthma in children.3
Suplatast tosylate is an anti-allergy, cytokine modulator.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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S Fatemeh Mousavi et al.
Bioorganic chemistry, 90, 103037-103037 (2019-06-19)
Capecitabine as a prodrug of 5-Fluorouracil plays an important role in the treatment of breast and gastrointestinal cancers. Herein, in view of the importance of this drug in chemotherapy, interaction mechanism between Capecitabine (CAP) and human serum albumin (HSA) as
Robert J Mallis et al.
Journal of biomolecular NMR, 73(6-7), 319-332 (2019-03-01)
Early studies of T cell structural biology using X-ray crystallography, surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) focused on a picture of the αβT cell receptor (αβTCR) component domains and their cognate ligands (peptides bound to MHC molecules
Vitor Hugo Bezerra et al.
Sensors (Basel, Switzerland), 19(14) (2019-07-25)
Internet of Things (IoT) devices have become increasingly widespread. Despite their potential of improving multiple application domains, these devices have poor security, which can be explored by attackers to build large-scale botnets. In this work, we propose a host-based approach
Sandhir B Prasad et al.
The American journal of cardiology, 124(3), 325-333 (2019-06-04)
The inter-relationships between minimal and maximal left atrial volume index (LAVI), left ventricular filling pressures and survival have not been well studied. This study aimed to compare LAVImin with LAVImax with respect to (1) relative prognostic value, and (2) correlation
Xin Huang et al.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 94(2), 172-180 (2019-01-29)
We sought to identify clinical, electrocardiographic (ECG), and angiographic characteristics that are predictive of 3-year mortality after primary percutaneous coronary intervention (PCI) in patients with non-anterior ST-elevation myocardial infarction (NA-STEMI) from the Harmonizing Outcomes With Revascularization and Stents in Acute
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