S3134

Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)

lyophilized powder, ≥2,000 units/mg solid

• Sinónimos: Streptokinase from Streptococcus hemolyticus
• Número de CAS: 9002-01-1
• Comisión internacional de enzimas: 3.4.99.0 (BRENDA, IUBMB)
• EC Number: 232-647-1
• MDL number: MFCD00082037
• UNSPSC Code: 12352204
• eCl@ss: 32160410
• NACRES: NA.54

Propiedades

• form: lyophilized powder
• specific activity: ≥2,000 units/mg solid
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
• InChI key: XRZWVSXEDRYQGC-UHFFFAOYSA-N

Descripción

General description

Research area: Cell signaling

Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.

Application

Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients.

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.

Biochem/physiol Actions

Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms. Streptokinase is effective in thrombolytic therapy. While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.

Unit Definition

One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.

Physical form

Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable