N0756

N-Nitrosodiethylamine

liquid, nitrosamine

• Sinónimos: Diethylnitrosamine
• Fórmula lineal: (C₂H₅)₂NNO
• Número de CAS: 55-18-5
• Peso molecular: 102.14
• Beilstein/REAXYS Number: 1744991
• EC Number: 200-226-1
• MDL number: MFCD00013890
• UNSPSC Code: 12352116
• PubChem Substance ID: 24897440
• NACRES: NA.77

Propiedades

• product name: N-Nitrosodiethylamine, liquid
• form: liquid
• color: yellow
• bp: 177 °C (lit.)
• density: 0.95 g/mL (lit.)
• SMILES string: CCN(CC)N=O
• InChI: 1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3
• InChI key: WBNQDOYYEUMPFS-UHFFFAOYSA-N

Descripción

General description

N-Nitrosodiethylamine belongs to the nitrosamines category of nitrogenous disinfection byproduct. It is also generated in chlorine based water treatment plants.

Application

N-Nitrosodiethylamine has been used to induce hepatocarcinogenesis in rat and mice.

Biochem/physiol Actions

N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde.

Packaging

Bulk Package

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H350,H412
• pcodes: P202 - P264 - P270 - P273 - P280 - P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter