475882-M

ML-9, Hydrochloride

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

• Sinónimos: ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
• Fórmula empírica (notación de Hill): C₁₅H₁₇ClN₂O₂S · xHCl
• Número de CAS: 105637-50-1
• Peso molecular: 324.83 (free base basis)
• MDL number: MFCD00065525
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: 50% ethanol: 10 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

Descripción

General description

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

Biochem/physiol Actions

Primary Target
Mlck

Target K_i: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute with aqueous buffer just prior to use.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable