370695

GW1929

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).

• Sinónimos: GW1929, PPAR Agonist V, PPARγ Agonist IV
• Fórmula empírica (notación de Hill): C₃₀H₂₉N₃O₄
• Número de CAS: 196808-24-9
• Peso molecular: 495.57
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• form: crystalline solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
• InChI key: QTQMRBZOBKYXCG-MHZLTWQESA-N

Descripción

General description

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine PPARγ and 6.2 nM for human PPARγ in cell-based transactivation assays).

A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays).

Biochem/physiol Actions

Cell permeable: no

EC50 = 13 nM as peroxisome proliferator-activated receptor γ (PPARγ) agonist for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays

Primary Target
Peroxisome proliferator-activated receptor γ (PPARγ) agonist

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Han, S., et al. 2004. Clin. Cancer Res.10, 1911.
Willson, T.M., et al. 2000. J. Med. Chem.43, 527.
Brown, K.K., et al. 1999. Diabetes48, 1415.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1