C-116

Clomipramine-d₃ hydrochloride solution

100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Sinónimos: Clomipramine-D₃ hydrochloride solution
• Fórmula empírica (notación de Hill): C₁₉D₃H₂₀ClN₂ · HCl
• Número de CAS: 1398065-86-5
• Peso molecular: 354.33
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H/i1D3;
• InChI key: WIMWMKZEIBHDTH-NIIDSAIPSA-N

Descripción

General description

Clomipramine is a tricyclic antidepressant used to many conditions from major depression and panic disorder to narcolepsy and obsessive compulsion disorder (OCD). This internal standard is is suitable for quantitation of Clomipramine levels in urine, serum, or plasma by LC/MS or GC/MS for applications in clinical toxicology, forensic analysis, isotope dilution methods, or pharmaceutical research.

Application

• Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression.: This study investigates the metabolic profiles in the brain following different administration routes of clomipramine in a rat model of depression, providing insights into its pharmacokinetics and pharmacodynamics (Abramova et al., 2021).
• Serotonergic regulation of the buccal (feeding) rhythm of the pond snail, Lymnaea stagnalis. An immunocytochemical, biochemical and pharmacological approach.: This research explores the serotonergic regulation in pond snails, employing clomipramine to understand its role in modulating neural rhythms, which has implications for understanding neurotransmitter systems (Elekes et al., 2018).
• Proteomic investigation of the prefrontal cortex in the rat clomipramine model of depression.: This study uses proteomic techniques to investigate changes in the prefrontal cortex of rats treated with clomipramine, contributing to the understanding of its impact on brain protein expression in depressive states (Gellén et al., 2017).
• A qualitative method for prediction of amine oxidation in methanol and water.: The paper presents a method for predicting amine oxidation, utilizing clomipramine as a case study, highlighting its importance in understanding chemical stability in various solvents (Bäcktorp et al., 2015).
• Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.: This research identifies potential biomarkers for drug-induced hepatic phospholipidosis, with clomipramine used to validate the biomarkers, aiding in the development of safer pharmaceuticals (Saito et al., 2014).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup