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Merck

122262

Sigma-Aldrich

N,N,N′,N′-Tetrakis(2-Hydroxypropyl)ethylenediamine

98%

Sinónimos:

Edetol, Entprol, (Ethylenedinitrilo)tetra-2-propanol, Quadrol®

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About This Item

Fórmula lineal:
[CH3CH(OH)CH2]2NCH2CH2N[CH2CH(OH)CH3]2
Número de CAS:
Peso molecular:
292.41
Beilstein/REAXYS Number:
1781143
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

vapor pressure

1 mmHg ( 20 °C)

assay

98%

refractive index

n20/D 1.4812 (lit.)

bp

175-181 °C/0.8 mmHg (lit.)

density

1.013 g/mL at 25 °C (lit.)

SMILES string

CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O

InChI

1S/C14H32N2O4/c1-11(17)7-15(8-12(2)18)5-6-16(9-13(3)19)10-14(4)20/h11-14,17-20H,5-10H2,1-4H3

InChI key

NSOXQYCFHDMMGV-UHFFFAOYSA-N

General description

N,N,N′,N′-Tetrakis(2-Hydroxypropyl)ethylenediamine (also known as Quadrol) is an ethylenediamine based monomer used in the production of polyurethane coatings, adhesives, cosmetics and personal care products. It can act as a chelating agent, due to the presence of its four hydroxyl groups, and a crosslinking agent, due to its two amino groups. It is widely used as a building block for polymers and copolymers, particularly those that are designed for use in UV-cross linkable polyurethane polymers, dendritic amino polymers, conducting polymers, inks, and coatings. Additionally, Quadrol is used in the production of resins, as well as in the manufacture of surfactants, plasticizers, and other chemical products.

Application

N,N,N′,N′-Tetrakis(2-Hydroxypropyl)ethylenediamine can be used as:
  • A monomer in the synthesis of covalently cross-linked and amorphous shape memory polyurethane (SMPU) foams that are used in biomedical applications, which includes SMPU actuators for treating ischemic stroke, thrombus removal activated by laser light, self-deployable SMP neuronal electrodes, vascular stents, sutures in microsurgery, ocular implants, bandages, cell manipulation, and cell therapy.
  • A precursor in the preparation of self-healing CFRPs (carbon fiber reinforced polymer) which are thermally responsive with excellent mechanical properties.
  • A crosslinking agent to create a hydrogel that is biocompatible and supports the growth of neural cells. Hydrogels are specifically designed to mimic the properties of the extracellular matrix (ECM), in promoting cell proliferation. The purpose of the hydrogel in this context is to act as an extracellular matrix (ECM) substitute, providing a supportive environment for cell growth and guiding cell adhesion and outgrowth. This study investigates the potential of the peptide-modified channels to facilitate neural tissue engineering and enhance cell proliferation within the hydrogel-based scaffold.

Legal Information

Quadrol is a registered trademark of BASF Corporation

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

411.8 °F - closed cup

flash_point_c

211 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves


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Thermally responsive self-healing composites with continuous carbon fiber reinforcement
Yunseon Heo and Henry A. Sodano
Composites Science and Technology, 118, 244-250 (2015)
Ona Gyliene et al.
Journal of hazardous materials, 175(1-3), 452-459 (2009-11-10)
Decontamination of solutions containing Cu(II) complexes with tartrate, glycine and quadrol (N,N,N'N'-tetrakis(2-hydroxypropyl)ethylenediamine) using metallic iron depends on pH and proceeds best in mildly acidic solutions. Cu(II) is completely removed from all solutions containing the ligands investigated. The degree of ligand
Low density biodegradable shape memory polyurethane foams for embolic biomedical applications
Pooja S, et al.
Acta Biomaterialia, 10(1), 67-76 (2014)
M V Bhide et al.
Journal of immunopharmacology, 7(3), 303-312 (1985-01-01)
Mouse peritoneal macrophages, when exposed to Quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine] in vitro, show a dose dependent enhanced spreading over a four-hour period. In vitro Quadrol induced phagocytosis of polystyrene beads was found to be time and concentration dependent. The rate and extent
Sarah J Stednitz et al.
Current biology : CB, 28(15), 2445-2451 (2018-07-31)
Deficits in social engagement are diagnostic of multiple neurodevelopmental disorders, including autism and schizophrenia [1]. Genetically tractable animal models like zebrafish (Danio rerio) could provide valuable insight into developmental factors underlying these social impairments, but this approach is predicated on

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