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Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells.

Scientific reports (2017-08-05)
Shiwen Han, Lu Sun, Feng He, Huilian Che
RÉSUMÉ

Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro. Active systemic allergic reaction in Balb/c mice showed that GA can suppress the increased level of IL-4 to restore the immune balance of T

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Sigma-Aldrich
Anticorps anti-dinitrophényle monoclonal antibody produced in mouse, IgE isotype, ~1 mg/mL, clone SPE-7, affinity purified immunoglobulin, buffered aqueous solution
Sigma-Aldrich
Fluo 3-AM solution, 1 mM in DMSO, ≥99.0% (TLC)