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Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (1984-01-01)
J Holm, S I Hansen, J Lyngbye
RÉSUMÉ

N10-methylfolate acted as a potent competitive inhibitor of high-affinity [3H] folate binding in human leukocytes, while methotrexate had no effect. Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate. Hence, in qualitative and quantitative respects, the substrate specificity characteristics of leukocyte folate binding resemble those of other high-affinity folate binding systems.

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Methotrexate impurity C, European Pharmacopoeia (EP) Reference Standard