Properties of several glycidyl methacrylate-triallyl isocyanurate based affinity adsorbents for removing circulating immune complexes.

Biocompatible affinity adsorbents prepared from macroporous glycidyl methacrylate-triallyl isocyanurate copolymer (GT) has been used for removing circulating immune complexes (CICs). In this work, adsorption of circulating immune complexes on GT-based affinity adsorbents has been studied by using batch and hemoperfusion studies. In batch mode, the equilibrium adsorption level was determined to be a function of the contact time, temperature, initial CIC concentration and adsorbent dosage. In animal hemoperfusion trials, removal of CICs is efficient and rapid. IgG, IgM and complement C3, C4 are minimally affected. There are negligible decreases in RBC, WBC, PLT and HB. Acid-base equilibrium, electrolytes and plasma proteins also are minimally affected.