Preparation, material properties and antimicrobial efficacy of silicone hydrogel by modulating silicone and hydrophilic monomer.

The present work proposes to investigate two series of silicone hydrogel materials for their characterization, water content, surface wettability, transmittance, mechanical property, oxygen permeability (Dk), and bacterial attachment as potential contact lens materials and discuss the relationships between water affinity and optical, mechanical, oxygen permeable and biological properties. One of the series of silicone hydrogels is presented on the basis of 3-(methacryloyloxy)propyltris(trimethylsiloxy)silane (TRIS), 3-(3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane (BIS) and 2-hydroxyethyl methacrylate (HEMA) with different silicone monomers/HEMA ratios. The other is presented on the basis of TRIS, BIS, HEMA and N,N-dimethylacrylamide (DMA) with different DMA/HEMA ratios. The results showed that the water affinity could be modulated by the hydrophilic methacrylate. The equilibrium water content (EWC) increased and the water static contact angle (WCA) value decreased with the increase of hydrophilic monomers. Overall, the results demonstrated that visible light transmittance tends to increase and tensile mechanical properties presented in declining trend depending on the increasing EWC. The Dk value decreased first and then increased when the EWC was from 20 to 60%. The reversion point of EWC was about 42.5% The amount of Staphylococcus aureus attached on the surface of the silicone hydrogels was dropped from 104 to 103 while the WCA was at 55°. This work may provide information on preparing functional silicone hydrogels for contact lenses application.