WH0001269M1

Monoclonal Anti-CNR2 antibody produced in mouse

clone 3C7, purified immunoglobulin, buffered aqueous solution

• Synonyme(s) : Anti-CB2, Anti-CX5, Anti-cannabinoid receptor 2 (macrophage)
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 3C7, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Technique(s): immunofluorescence: suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• Isotype: IgG1κ
• Numéro d'accès GenBank: NM_001841.1
• Numéro d'accès UniProt: P34972
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CNR2(1269)

Description

Description générale

Cannabinoid receptor 2 (CNR2) is encoded by the gene mapped to human chromosome 1p36.11. The encoded protein belongs to a novel cadherin-related multigene family. Members of this family contain six cadherin repeats and conserved DXNDNXPXF and DXD motifs with constitute putative calcium-binding sequences.

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. (provided by RefSeq)

Immunogène

CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

Application

Monoclonal Anti-CNR2 antibody produced in mouse has been used in western blot analysis.

Actions biochimiques/physiologiques

Cannabinoid receptor 2 (CNR2) plays a crucial role in mediating anti-inflammatory and anti-atherosclerotic effects in vivo. It is also involved in cancer, bone metabolism and pain perception. CNR2 might be implicated in selective cell–cell interaction. Mutations in the gene has been associated with trochanter and hip bone mineral density (BMD).

Forme physique

Solution in phosphate buffered saline, pH 7.4

Informations légales

GenBank is a registered trademark of United States Department of Health and Human Services

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)