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SAB4200840

Sigma-Aldrich

Anti-Pro LC3C antibody, Mouse monoclonal

clone BTY-1, purified from hybridoma cell culture Affinity isolated antibody

Synonyme(s) :

Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B LC3 C, MAP1A/MAP1B light chain 3 C, Microtubule-associated protein 1 light chain 3 gamma, Microtubule-associated proteins 1A/1B light chain 3C

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Type de produit anticorps

primary antibodies

Clone

BTY-1, monoclonal

Forme

liquid

Espèces réactives

human

Conditionnement

antibody small pack of 25 μL

Concentration

~1 mg/mL

Technique(s)

immunoblotting: 0.5-1 μg/mL using whole extracts of HEK-293T cells overexpressing human LC3C

Isotype

IgG1

Numéro d'accès UniProt

Q9BXW4

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MAP1LC3C(440738)

Description générale

Monoclonal Anti-Pro LC3C antibody (mouse IgG1 isotype) is derived from the BTY-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse. Human microtubule-associated proteins 1 light chain 3 (LC3C) is an ortholog of yeast Atg8. It is expressed in different human tissues. LC3C belongs to the subfamily of LC3 and the family of human Atg8. It is a structural protein of the autophagosomal membrane. LC3C gene is located on the human chromosome at 1q43.

Spécificité

Monoclonal Anti-Pro LC3C antibody specifically recognizes epitope at the C-terminal pro-peptide domain of human LC3C-I and/or LC3C-II and dose not cross react with human LC3A or LC3B.

Immunogène

Synthetic peptide corresponding to the C-terminal region of human LC3C, conjugated to KLH

Application

Anti-Pro LC3C antibody, mouse monoclonal may be used in immunoblotting and immunofluorescence.

Actions biochimiques/physiologiques

Human microtubule-associated proteins 1 light chain 3 (LC3C) protein is considered as an autophagy marker. It enhances the trafficking of hepatocyte growth factor (Met) receptor tyrosine kinase (RTK) to an autophagic compartment. LC3C protein also plays a role in antibacterial autophagy.

Forme physique

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Stockage et stabilité

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Clause de non-responsabilité

Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines
Koukourakis M I, et al.
PLoS ONE, 10(9), e0137675-e0137675 (2015)
LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion
Bell E S, et al.
Testing, 29(12), 4053-4068 (2019)
Natalia von Muhlinen et al.
Molecular cell, 48(3), 329-342 (2012-10-02)
Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation. Autophagy receptors target cargo to autophagy by binding ATG8 on autophagosomal membranes. The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions with

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