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Key Documents

S7696

Sigma-Aldrich

Anti-Sec23 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Sec23-related protein A, Anti-Sec23A, Anti-protein transport protein Sec23A

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~75 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

indirect immunofluorescence: 5-10 μg/mL using human HeLa cells
western blot (chemiluminescent): 1-2 μg/mL using whole extracts of mouse NIH-3T3 and rat ROS cells

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SEC23A(10484)
mouse ... Sec23a(20334)
rat ... Sec23a(58817)

Description générale

Sec23 has two isoforms, Sec23A and Sec23B. Sec23A is mainly found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles.
Sec23A (Sec23 homolog A) is a human Sec23 paralog, that is a GTPase-activating protein. It is a fundamental constituent of the coat protein II complex. It is located on human chromosome 14q21.

Immunogène

synthetic peptide corresponding to amino acid residues 1-18 of human Sec23A with C-terminal added cysteine conjugated to KLH. The corresponding sequence is identical in rat and mouse Sec23A and differs by one amino acid in human and mouse Sec23B.

Application

Anti-Sec23 antibody has been used in immunoblotting, in western blot analysis, immunofluorescence.

Actions biochimiques/physiologiques

Sec23A (Sec23 homolog A) plays an important role in protein trafficking between the endoplasmic reticulum and Golgi apparatus. It also participates in anti-tumorigenesis. Suppressing the expression of Sec23A induces multiplication, migration, and invasion of CRC cells (colorectal cancer). Mutation in SEC23A gene results in cranio-lenticulo-sutural dysplasia.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction
Leonhardt RM, et al.
The Journal of Biological Chemistry, 285(21), 16166-16183 (2010)
Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport
Cutrona M B, et al.
Traffic, 14(6), 691-708 (2013)
The RAB11A-positive compartment is a primary platform for autophagosome assembly mediated by WIPI2 recognition of PI3P-RAB11A
Puri C, et al.
Developmental Cell, 45(1), 114-131 (2018)
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
Garcia I A, et al.
Journal of Cell Science, 130(24), 4155-4167 (2017)
Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma
Szczyrba J, et al.
Molecular Cancer Research, 9(6), 791-800 (2011)

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