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S1450

Sigma-Aldrich

Anti-Superoxide Dismutase (MnSOD) (DD-17)−Cy3 antibody produced in rabbit

1-2 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-IPO-B, Anti-Indophenoloxidase B, Anti-MNSOD, Anti-Manganese Superoxide Dismutase 2, Anti-Manganese dependent SOD, Anti-Mitochondrial SOD, Anti-SOD2, Anti-Superoxide dismutase 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.43

Source biologique

rabbit

Conjugué

CY3 conjugate

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human, rat, mouse

Conditionnement

antibody small pack of 25 μL

Concentration

1-2 mg/mL

Technique(s)

direct immunofluorescence: 2-5 μg/mL using human HeLa, rat NRK and mouse 3T3 cells.

Numéro d'accès UniProt

P04179

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SOD2(6648)

Catégories apparentées

Description générale

The SOD2 (superoxide dismutase 2) gene is mapped to human chromosome 6q25.3. The encoded protein functions as a tetramer and is localized to mitochondria.

Immunogène

synthetic peptide corresponding to amino acid residues 183-199 of human superoxide dismutase (MnSOD), conjugated to KLH. The corresponding sequence is conserved in many eukaryotes.

Application

Anti-Superoxide Dismutase (MnSOD) (DD-17)-Cy3 antibody produced in rabbit has been used in immunohistochemistry.

Actions biochimiques/physiologiques

Superoxide dismutase 2 (SOD2) is an antioxidant enzyme and catalyzes the conversion of superoxide to hydrogen peroxide and molecular oxygen. The enzyme offers protection against oxidative damage induced by reactive oxygen species and is also radioprotective. The gene is associated with the metastasis and invasion process of salivary adenoid cystic carcinoma. Manganese SOD is involved in detoxification.

Forme physique

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Patrick D Bhola et al.
The Journal of clinical investigation, 126(10), 3827-3836 (2016-09-07)
Upfront resistance to chemotherapy and relapse following remission are critical problems in leukemia that are generally attributed to subpopulations of chemoresistant tumor cells. There are, however, limited means for prospectively identifying these subpopulations, which hinders an understanding of therapeutic resistance.
Substrate-analog binding and electrostatic surfaces of human manganese superoxide dismutase.
Azadmanesh J, et al.
Journal of Structural Biology, 199(1), 68-75 (2017)
SOD2 deregulation enhances migration, invasion and has poor prognosis in salivary adenoid cystic carcinoma.
Chang B, et al.
Scientific Reports, 6, 25918-25918 (2016)
Radiation-induced SOD2 overexpression sensitizes colorectal cancer to radiation while protecting normal tissue.
Zhang Z, et al.
Oncotarget, 8(5), 7791-7791 (2017)
Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma.
Li S, et al.
Oncotarget, 7(22), 32408-32408 (2016)
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