P7854

Anti-Presenilin-1 (S182) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonyme(s) : Anti-ACNINV3, Anti-AD3, Anti-FAD, Anti-PS-1, Anti-PS1, Anti-S182
• Numéro MDL: MFCD02097229
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: IgG fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Espèces réactives: mouse, human, Xenopus, rat
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain; microarray: suitable; western blot: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line
• Numéro d'accès UniProt: P49768
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PSEN1(5663) ; mouse ... Psen1(19164) ; rat ... Psen1(29192)

Description

Description générale

Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.

Spécificité

Specific for presenilin 1 (not found in presenilin 2) and is identical in mouse, rat, and Xenopus. By immunoblotting, the antibody reacts with presenilin 1 (PS1, S182) and with the PS1 cleavage product.

Immunogène

synthetic peptide corresponding to the C-terminal of human presenilin-1 (amino acids 450-467 with N-terminally added lysine) conjugated to KLH.

Application

Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:

• immunostaining
• immunofluorescence detection
• immunohistochemistry
• immunoblotting

Actions biochimiques/physiologiques

The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids