P1093

Monoclonal Anti-Paxillin antibody produced in mouse

clone PXC-10, ascites fluid

• Numéro MDL: MFCD00212475
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Conjugué: unconjugated
• Forme d'anticorps: ascites fluid
• Type de produit anticorps: primary antibodies
• Clone: PXC-10, monoclonal
• Poids mol.: antigen 68-40 kDa
• Contient: 15 mM sodium azide
• Espèces réactives: bovine, rat, human, chicken, hamster
• Technique(s): immunocytochemistry: suitable; microarray: suitable; western blot: 1:500 using a cultured human cell line extract
• Isotype: IgG1
• Numéro d'accès UniProt: P49023
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PXN(5829) ; rat ... Pxn(360820)

Description

Description générale

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

Spécificité

Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

Immunogène

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

Application

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

Actions biochimiques/physiologiques

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable