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L6135

Sigma-Aldrich

Lectin from Arachis hypogaea (peanut)

biotin conjugate, lyophilized powder

Synonyme(s) :

PNA, Peanut agglutinin

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Conjugué

biotin conjugate

Niveau de qualité

200

Forme

lyophilized powder

Poids mol.

120 kDa

Composition

Protein, ≥80% Lowry

Ampleur du marquage

~3 mol biotin per mol protein

Technique(s)

blood typing: suitable
fractionation: suitable

Solubilité

water: 1.00-1.10 mg/mL, clear to slightly hazy, colorless

Température de stockage

2-8°C

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Description générale

Peanut lectin (PNA) is a lectin or an agglutinin from the legume, Arachis hypogaea, found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3) N-acetylgalactosamine.

Application

Lectin from Arachis hypogaea (peanut) has been used:
  • in enzyme-linked micro plate assay to detect β-D-galactose-N-acetylglucosamine
  • in Immunohistochemical double staining
  • Immunohistochemical double staining for the detection of germinal centers
  • in enzyme-linked microplate assayto detect β-D-galactose-N-acetylglucosamine

Actions biochimiques/physiologiques

Lectin from Arachis hypogaea (peanut) functions as an antigenic determinant for Thomsen-Friedenreich antigen (TF) and as mitogen for colorectal cancer stimulation cell division in normal colonic epithelium. It is therefore used as tumor marker.
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.

Conditionnement

Package size based on protein content.

Forme physique

Contains sodium citrate

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Inhibition of influenza viral neuraminidase activity by collectins
Tecle T, et al.
Archives of Virology, 1731-1742 (2007)
In situ observation of germinal center cell apoptosis during a secondary immune response
Saitoh HA, et al.
Journal of Clinical and Experimental Hematopathology : JCEH, 46, 73-82 (2006)
Andreia Valença et al.
Experimental eye research, 202, 108292-108292 (2020-10-17)
Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has
Peanut lectin stimulates proliferation of colon cancer cells by interaction with glycosylated CD44v6 isoforms and consequential activation of c-Met and MAPK: functional implications for disease-associated glycosylation changes
Glycobiology, 16(7), 594-601 (2006)
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus--infected mice
GeurtsvanKessel CH, et al.
The Journal of Experimental Medicine, 206, 2339-2349 (2009)
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