I8273
Anti-Interleukin-2 antibody produced in goat
IgG fraction of antiserum, lyophilized powder
Synonyme(s) :
Anti-IL-2
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About This Item
Produits recommandés
Source biologique
goat
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
IgG fraction of antiserum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized powder
Espèces réactives
human
Technique(s)
neutralization: suitable
western blot: 1 μg/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... IL2(3558)
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Description générale
Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4+ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.
Spécificité
The antibody neutralizes the biological activity of recombinant human IL-2.
Immunogène
recombinant human interleukin-2 expressed in Escherichia coli.
Application
Anti-interleukin-2 antibody is suitable for IL-2 neutralization assays.
Forme physique
Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.
Notes préparatoires
Purified using protein G.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Matthew A Williams et al.
Nature, 441(7095), 890-893 (2006-06-17)
Although interleukin-2 (IL-2) was initially characterized as the primary T-cell growth factor following in vitro activation, less is known about its role in shaping T-cell responses to acute infections in vivo. The use of IL-2- or IL-2-receptor-deficient mice is problematic
Hans Dooms et al.
Journal of immunology (Baltimore, Md. : 1950), 172(10), 5973-5979 (2004-05-07)
The acquisition of long-term survival potential by activated T lymphocytes is essential to ensure the successful development of a memory population in the competitive environment of the lymphoid system. The factors that grant competitiveness for survival to primed T cells
B H Nelson et al.
Advances in immunology, 70, 1-81 (1998-10-02)
Studies of the biology of the IL-2 receptor have played a major part in establishing several of the fundamental principles that govern our current understanding of immunology. Chief among these is the contribution made by lymphokines to regulation of the
Arian Laurence et al.
Immunity, 26(3), 371-381 (2007-03-17)
Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory
Katrina K Hoyer et al.
Immunological reviews, 226, 19-28 (2009-01-24)
Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T-helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the
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