GW22461F
Anti-Interleukin-2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
chicken
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
rat, mouse, human
Fabricant/nom de marque
Genway 15-288-22461F
Technique(s)
indirect ELISA: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... IL2(3558)
Description générale
IL2 (interleukin 2) is a pro-inflammatory cytokine, which is predominantly synthesized by activated T-cells and dendritic cells (DCs). T-cells also act as effector of IL-2 as they contain the interleukin 2 receptor (IL2R). This gene is localized to human chromosome 4q27, and codes for a glycoprotein with a molecular weight of 14-17kDa.
Application
Anti-Interleukin-2 antibody produced in chicken is suitable for the production of anti-IL2 surface-conjugated microtoroids. It is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Actions biochimiques/physiologiques
Interleukin 2 (IL-2) is an interleukin and is a cytokine signaling molecule in the immune system. It plays an important role in signal transduction for biological functions of IL-2. Upregulation of IL-2 combined with activation of IL-2-dependent signaling pathways may contribute to the pathogenesis of Focal cortical dysplasia (FCD). Aerosol interleukin-2 (IL-2) increases the number of intravenously injected human natural killer (NK) cells in the lungs by stimulating local NK cell proliferation. The effect on NK cell proliferation is organ specific, which makes it ideal for the specific targeting of lung metastasis.
Forme physique
Solution in phosphate buffered saline containing 0.02% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Hunter A Martinez et al.
Nature communications, 15(1), 1564-1564 (2024-02-21)
Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that
Wei Guo et al.
Journal of neuropathology and experimental neurology, 73(3), 206-222 (2014-02-04)
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs)
Marta Fichna et al.
Molecular biology reports, 40(12), 6957-6963 (2013-10-25)
Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune disorders. Our aim was to evaluate the association of the four IL2 polymorphisms (rs6822844, rs6534349, rs2069762 and rs3136534) with type 1 diabetes (T1D) in the Polish population
Marcel Joly et al.
Journal of theoretical biology, 335, 57-78 (2013-06-29)
In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the G1
Jipseol Jeong et al.
Veterinary immunology and immunopathology, 162(3-4), 154-161 (2014-12-03)
Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the
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