F7876

Folic acid

≥97%

• Synonyme(s) : PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Formule empirique (notation de Hill) : C₁₉H₁₉N₇O₆
• Numéro CAS: 59-30-3
• Poids moléculaire : 441.40
• Beilstein: 100781
• Numéro CE : 200-419-0
• Numéro MDL: MFCD00079305
• Code UNSPSC : 12352106
• eCl@ss : 34058014
• ID de substance PubChem : 57654192
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic (organic)
• Essai: ≥97%
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: faint orange to dark orange-yellow; faint yellow to dark yellow
• Pf: >285 °C
• Température de stockage: room temp
• Chaîne SMILES: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• Clé InChI: OVBPIULPVIDEAO-LBPRGKRZSA-N

Description

Application

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Actions biochimiques/physiologiques

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)