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F2379

Sigma-Aldrich

Fetuin from fetal calf serum

lyophilized powder, suitable for cell culture

Synonyme(s) :

Fetuin from fetal calf serum

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About This Item

Numéro CAS:
9014-81-7
Numéro CE :
232-762-7
Numéro MDL:
MFCD00131055
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61

Source biologique

bovine serum (fetal)

Forme

lyophilized powder

Technique(s)

cell culture | mammalian: suitable

Impuretés

≤0.3% free N-acetylneuraminic acid

Solubilité

H2O: 1 mg/mL, colorless to faint yellow or tan

Numéro d'accès UniProt

Q58D62

Température de stockage

2-8°C

Informations sur le gène

bovine ... FETUB(504615)

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Description générale

Fetuin from fetal bovine serum is a 64 kDa plasma glycoprotein. It is produced by the liver and adipose tissue.

Application

Fetuin from fetal bovine serum has been used:
  • to synthesize primary and secondary calciprotein particles (CPP)
  • to study the binding of Xerocomus chrysenteron lectin (XCL) to the T antigen expressed by membrane proteins
  • as a supplement in Ham′s F10 media for myoblast culture.

Fetuin is a protein with the ability to bind to the insulin receptor and inhibit insulin action. Fetuin has been used in studies of type 2 diabetes mellitus (T2DM). In patients with T2DM, fetuin has been shown to be significantly lower when compared to control patients. Fetuin has also been used in studies to demonstrate its protective role in the development of arterial calcification.

Actions biochimiques/physiologiques

Fetuin, an inhibitor of insulin receptor tyrosine kinase, modulates bone remodeling and calcium metabolism. It is involved in keratinocytes migration and breast tumor cell proliferative signaling. Fetuin also regulates vascular calcification, insulin resistance and protease activity It acts as a biomarker for neurodegenerative diseases. Fetuin has anti-inflammatory property.

Notes préparatoires

Prepared by ammonium sulfate fractionation of fetal bovine serum by the method of Pederson, K.O., J. Phys. and Colloid Chem., 51, 164 (1947).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity
Koeppert S, et al.
Frontiers in Immunology, 9, 1991-1991 (2018)
Pietro Allevi et al.
Journal of chromatography. A, 1212(1-2), 98-105 (2008-10-28)
The present report describes a method for the quantification of N-acetyl- and N-glycolylneuraminic acids without any derivatization, using their (13)C(3)-isotopologues as internal standards and a C(18) reversed-phase column modified by decylboronic acid which allows for the first time a complete
Kevan L Hartshorn et al.
American journal of physiology. Lung cellular and molecular physiology, 298(1), L79-L88 (2009-10-20)
Collectins are collagenous lectins present in blood, respiratory lining fluid, and other mucosal secretions that play important roles in innate defense against infection. The collectin, surfactant protein D (SP-D), limits infection by viruses and bacteria in the respiratory tract, eye
A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery
Ladurantie C, et al.
Nanoscale, 11(7), 3248-3260 (2019)
mTORC1 regulates mitochondrial integrated stress response and mitochondrial myopathy progression
Khan NA, et al.
Cell Metabolism, 26(2), 419-428 (2017)
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