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D1881

Sigma-Aldrich

Dexamethasone 21-acetate

≥99%

Synonyme(s) :

9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Formule empirique (notation de Hill):
C24H31FO6
Numéro CAS:
1177-87-3
Poids moléculaire :
434.50
Numéro Beilstein :
2342608
Numéro CE :
214-646-8
Numéro MDL:
MFCD00027407
Code UNSPSC :
51422333
ID de substance PubChem :
24893562
Nomenclature NACRES :
NA.77

Pureté

≥99%

Forme

powder

Température de stockage

2-8°C

Chaîne SMILES 

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

Clé InChI

AKUJBENLRBOFTD-RPRRAYFGSA-N

Informations sur le gène

human ... NR3C1(2908)

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Application

Dexamethasone 21-acetate has been used:
  • as a component of the induction medium for the treatment of mice preadipocytes (5A) cells
  • as a synthetic glucocorticoid to study its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in placentas of human and mice
  • as a component of the complete medium for the culturing of porcine hepatocytes

Actions biochimiques/physiologiques

Dexamethasone 21-acetate or dexamethasone acetate is a derivative of dexamethasone. It is a hydrophobic drug. Dexamethasone is a glucocorticoid possessing anti-inflammatory activity.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360FD

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media
Caperna T J, et al.
In Vitro Cellular & Developmental Biology. Animal, 47(3), 218-233 (2011)
F Ceccato et al.
Journal of endocrinological investigation, 43(8), 1105-1113 (2020-02-16)
Dexamethasone Suppression Test (DST), recommended for Cushing's Syndrome (CS) diagnosis, explores the pituitary feedback to glucocorticoids. Its diagnostic accuracy could be affected by dexamethasone bioavailability, and therefore, we have developed and validated a dexamethasone threshold after 1-mg DST. We studied
Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels
Carrer1 A, et al.
The Journal of Biological Chemistry, 5(1-2), 487-487 (2017)
Dexamethasone transport and ocular delivery from poly (hydroxyethyl methacrylate) gels
Kim J and Chauhan A
International Journal of Pharmaceutics, 353(1-2), 205-222 (2008)
Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat
Acar N, et al.
Acta Histochemica, 116(8), 1289-1300 (2014)
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