C8011

Chelidamic acid hydrate

≥95%, powder

• Synonyme(s) : 1,4-Dihydro-4-oxo-2,6-pyridinedicarboxylic acid hydrate, 4-Hydroxypyridine-2,6-dicarboxylic acid
• Formule empirique (notation de Hill): C₇H₅NO₅ · xH₂O
• Numéro CAS: 138-60-3
• Poids moléculaire : 183.12 (anhydrous basis)
• Numéro Beilstein : 476229
• Numéro CE : 205-335-8
• Numéro MDL: MFCD03818117
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278338
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Pureté: ≥95%
• Forme: powder
• Couleur: brown
• Pf: 267 °C (dec.) (lit.)
• Solubilité: 1 M NH4OH: 50 mg/mL, clear to slightly hazy
• Chaîne SMILES: O.OC(=O)C1=CC(=O)C=C(N1)C(O)=O
• InChI: 1S/C7H5NO5.H2O/c9-3-1-4(6(10)11)8-5(2-3)7(12)13;/h1-2H,(H,8,9)(H,10,11)(H,12,13);1H2
• Clé InChI: SNGPHFVJWBKEDG-UHFFFAOYSA-N

Description

Application

Chelidamic acid hydrate has been used in eluent solution as a complexing additive in high-performance chelation ion chromatography (HPCIC) for speciation of iron. It has also been used as an organic ligand for the polyoxometalate (POM)-based lanthanoid hybrid compounds.

Actions biochimiques/physiologiques

Chelidamic acid (CDA), a hydroxylated derivative of 2,6-pyridine-dicarboxylic acid (DPA), is a trianionic chelating agent.

Among the most potent of the tested "conformationally restricted glutamate analogs" as an inhibitor of glutamate decarboxylase.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves