A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Synonyme(s) : 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Formule empirique (notation de Hill): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• Numéro CAS: 160928-38-1
• Poids moléculaire : 785.05 (anhydrous basis)
• Numéro MDL: MFCD12910436
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278252
• Nomenclature NACRES : NA.77

Propriétés

• product name: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: white to off-white
• Solubilité: H₂O: >20 mg/mL; DMSO: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• Clé InChI: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Informations sur le gène: human ... ENTPD2(954)

Description

Description générale

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Application

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Actions biochimiques/physiologiques

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3