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Key Documents

356M-1

Sigma-Aldrich

Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

D5 & 16B4, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (356M-14)
vial of 0.5 mL concentrate (356M-15)
bottle of 1.0 mL predilute (356M-17)
vial of 1.0 mL concentrate (356M-16)
bottle of 7.0 mL predilute (356M-18)

Fabricant/nom de marque

Cell Marque

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

Isotype

IgG1

Contrôle

mesothelioma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... KRT5(3852)

Description générale

Anti-CK 5 & 6 positivity is seen in 65% to 100% of epithelioid mesotheliomas, in 0% to 19% of lung adenocarcinomas, and in 22% to 80% of serous carcinoma of the ovary and peritoneum. Keratin 5 & 6 expression in lung adenocarcinoma is not common, and when it occurs, the reaction is usually confined to small focal areas or scattered cells. The most probable cause of this finding is the presence of squamous differentiation of lung adenocarcinoma. Anti-CK 5 & 6 positivity has been useful in recognizing squamous cell carcinoma of the skin. Less than 10% of carcinomas of the breast, colon, and prostate stain positively for this marker. Anti-CK 5 & 6 has also been used successfully as a myoepithelial cell marker in the prostate and breast to determine malignancy. Anti-CK 5 & 6 is a useful marker to distinguish lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma within a panel including antibodies against TTF-1, Napsin A, p63, SOX-2, desmocollin3, and desmoglein3.

Qualité


IVD

IVD

IVD

RUO

Liaison

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Consulter la Bibliothèque de documents

Neil A Abrahams et al.
American journal of clinical pathology, 120(3), 368-376 (2003-09-25)
We evaluated the sensitivity and specificity of cytokeratin (CK) 5/6 for distinguishing foci of atrophy from prostatic adenocarcinoma with and without previous hormonal adjuvant therapy and observed the intensity and pattern of staining in mimickers of prostatic adenocarcinoma (basal cell
Magali Lacroix-Triki et al.
Virchows Archiv : an international journal of pathology, 442(6), 548-554 (2003-04-25)
Previous studies have shown that basal-type cytokeratins (CKs) can distinguish usual ductal hyperplasia (UDH) from the spectrum of atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS). Indeed, expression of these CKs is weak
Peiguo G Chu et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 15(1), 6-10 (2002-01-18)
Cytokeratin 5/6 (CK 5/6) immunoreactivity has been observed in the vast majority of cases of malignant mesothelioma but only rarely in pulmonary adenocarcinomas. Thus, CK 5/6 has been used to distinguish malignant mesothelioma from pulmonary adenocarcinoma. However, the utility of
F Otterbach et al.
Histopathology, 37(3), 232-240 (2000-09-06)
This study was performed to determine the diagnostic value of keratin 5/6 (CK 5/6) immunophenotyping on routinely processed breast tissues. Six hundred and ninety-nine breast lesions, including normal tissues as well as benign and malignant lesions in 321 formalin-fixed, paraffin-embedded
J E Sigel et al.
Journal of cutaneous pathology, 28(10), 520-524 (2001-12-12)
Cutaneous spindle cell squamous cell carcinoma (SSCC) is a challenging diagnosis since it may be difficult to distinguish from spindle cell melanoma, leiomyosarcoma and atypical fibroxanthoma. Furthermore, it may be difficult to demonstrate epithelial differentiation by a traditional immunohistochemical panel.

Contenu apparenté

Un bref aperçu de l'immunohistochimie (IHC) pour le diagnostic et de son importance en biologie médicale moderne. Apprenez-en davantage sur l'IHC et sur son rôle dans le diagnostic des cancers et la détection des maladies infectieuses.

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.

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