294R-1

BOB.1 (SP92) Rabbit Monoclonal Antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100; 500
• Conjugué: unconjugated
• Forme d'anticorps: culture supernatant
• Type de produit anticorps: primary antibodies
• Clone: SP92, monoclonal
• Description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (294R-14); vial of 0.5 mL concentrate (294R-15); bottle of 1.0 mL predilute (294R-17); vial of 1.0 mL concentrate (294R-16); bottle of 7.0 mL predilute (294R-18)
• Fabricant/nom de marque: Cell Marque^™
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotype: IgG1
• Contrôle: B-cell lymphoma, tonsil
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: nuclear
• Informations sur le gène: human ... POU2AF1(5450)

Description

Description générale

Expression of BOB.1/OBF.1 is restricted largely to mature B-cells. Germinal center B-cells normally demonstrate strong staining for BOB.1, as do mantle-zone B-cells, and plasma cells. Analyses of BOB.1/OBF.1 expression in a variety of established B-cell lines representing different stages of B-cell development has suggested a constitutive, B-cell-specific expression pattern. Because they are germinal center derived, L&H cells in nodular lymphocyte predominant Hodgkin lymphoma are consistenty immunoreactive for BOB.1. Conversely, the Hodgkin/Reed- Sternberg cells in classical Hodgkin lymphoma either do not express both (80%) or express only one (20%) of the two proteins. In B-cell lymphomas, the highest expression levels for BOB.1/OBF.1 are reported in follicular center lymphomas, diffuse large B-cell lymphomas and Burkitt lymphomas.B-CLL, MALT-type, and mantle cell lymphomas score negative or display an heterogenous/weaker reactivity.10-11 Studies have suggested that anti-BOB. has a high predictive value in discriminating primary mediastinal B-cell lymphoma from classical Hodgkin disease.Approximately 50% of acute myeloid leukemias express BOB.1.

Liaison

BOB.1 Positive Control Slides, Product No. 294S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

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Autres remarques

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Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany