PHR1098
N-Acetyl-L-cysteine
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
LNAC, NAC
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule linéaire :
HSCH2CH(NHCOCH3)CO2H
Numéro CAS:
Poids moléculaire :
163.19
Numéro Beilstein :
1724426
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
Produits recommandés
Qualité
certified reference material
pharmaceutical secondary standard
Niveau de qualité
Agence
traceable to BP 907
traceable to Ph. Eur. A0150000
traceable to USP 1009005
Famille d'API
acetylcysteine
CofA (certificat d'analyse)
current certificate can be downloaded
Conditions de stockage
protect from light
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Pf
106-108 °C (lit.)
Application(s)
pharmaceutical (small molecule)
Format
neat
Température de stockage
2-8°C
Chaîne SMILES
CC(=O)N[C@@H](CS)C(O)=O
InChI
1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1
Clé InChI
PWKSKIMOESPYIA-BYPYZUCNSA-N
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
Description générale
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine. It finds use in clinical applications as a mucolytic agent typically administered by inhalation.
N-Acetyl-L-cysteine is an endogenous aminothiol which is a component of human plasma and urine. It finds use in clinical applications as a mucolytic agent typically administered by inhalation.
Application
N-Acetyl-L-cysteine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography-mass spectrometry (LC-MS) and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Actions biochimiques/physiologiques
Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.
Remarque sur l'analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Autres remarques
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Note de bas de page
To see an example of a Certificate of Analysis for this material enter LRAC0297in the slot below. This is an example certificate only and may not be the lot that you receive.
Produits recommandés
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Faites votre choix parmi les versions les plus récentes :
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Spectrophotometric determination of N-acetyl-L-cysteine and N-(2-mercaptopropionyl)-glycine in pharmaceutical preparations.
Kukoc-Modun L and Radic N
International Journal of Analytical Chemistry, 2011(1-2), 191-199 (2011)
Quantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by liquid chromatography-UV detection-mass spectrometry.
Toussaint B,
Journal of Chromatography A, 896(1-2), 191-199 (2000)
Pharmacokinetics of N-acetylcysteine in man.
Borgstrom L, et al.
European Journal of Clinical Pharmacology, 31(2), 217-222 (1986)
Eduesley Santana-Santos et al.
The Annals of thoracic surgery, 97(5), 1617-1623 (2014-03-25)
The renoprotective effect of N-acetylcystein in patients undergoing coronary artery bypass graft surgery is controversial. We assessed the renoprotective effect of the highest dose of N-acetylcystein sanctioned for clinical use in a prospective, double-blind, placebo-controlled study including 70 chronic kidney
Michael Berk et al.
Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique