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00881

Supelco

(±)-4-Hydroxypropranolol hydrochloride

analytical standard

Synonyme(s) :

1-[(4-Hydroxy-1-naphthyl)oxy]-3-(isopropylamino)- 2-propanol hydrochloride, 4′-Hydroxypropranolol hydrochloride, 4-{2-Hydroxy-3-[(1-methylethyl)amino]propoxy}-1-naphthalenol hydrochloride

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About This Item

Formule empirique (notation de Hill):
C16H21NO3·HCl
Numéro CAS:
14133-90-5
Poids moléculaire :
311.80
Numéro Beilstein :
4036845
Numéro MDL:
MFCD06656370
Code UNSPSC :
41116107
ID de substance PubChem :
329747156
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Pureté

≥98.5% (AT)
≥98.5% (HPLC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

CC(C)NCC(O)COC1=CC=C(O)C2=CC=CC=C21.Cl

InChI

1S/C16H21NO3.ClH/c1-11(2)17-9-12(18)10-20-16-8-7-15(19)13-5-3-4-6-14(13)16;/h3-8,11-12,17-19H,9-10H2,1-2H3;1H

Clé InChI

ROUJENUXWIFONU-UHFFFAOYSA-N

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
BCCL5746
BCCH1537
BCCC6246
BCBV6968
BCBL8519V

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T D Eller et al.
Journal of chromatography, 612(2), 320-325 (1993-02-26)
Selective extraction of sulfate conjugates of basic drugs from biological matrices has been difficult because of their highly polar nature. Immunoaffinity isolation may be the best solution to this analytical problem. This was tested for a model compound, the metabolite
V G Belolipetskaia et al.
Eksperimental'naia i klinicheskaia farmakologiia, 58(6), 56-59 (1995-11-01)
Pharmacokinetics of propranolol (P), 4-hydroxy-propranolol sulfate (4HOP-Sulf), and glucoronides of pharmacologically active S-enantiomer P (S-PG) and ballast R-enantiomer of P (R-PG) in the blood serum of 21 patients with chronic ischemic heart disease and/or arterial hypertension has been studied at
Junko Miyano et al.
Biochemical pharmacology, 69(6), 941-950 (2005-03-08)
Pretreatment of Hep G2 cells with beta-naphthoflavone (BNF 1-25microM) significantly increased cytosolic sulfation activities of 4-hydroxypropranolol (4-OH-PL) racemate. The profile was similar to those of sulfations towards dopamine and triiodothyronine in the same cytosolic fractions. Kinetic studies of 4-OH-PL sulfation
Pankaj Partani et al.
Journal of pharmaceutical and biomedical analysis, 50(5), 966-976 (2009-07-31)
A very sensitive, reliable, reproducible and highly selective assay for the simultaneous determination of free and total (conjugated and unconjugated) propranolol and its equipotent hydroxyl metabolite, 4-hydroxy propranolol, in human plasma was developed and validated. The analytes were simultaneously extracted
Takeshi Shimizudani et al.
Chemico-biological interactions, 183(1), 67-78 (2009-10-27)
Oxidative metabolism of propranolol (PL) enantiomers (R-PL and S-PL) to 4-hydroxypropranolol (4-OH-PL), 5-OH-PL and N-deisopropylpropranolol (NDP) was examined in hepatic microsomes from cynomolgus and marmoset monkeys and in small intestinal microsomes from monkeys and humans. In hepatic microsomes, levels of
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