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Key Documents

OP80

Sigma-Aldrich

Anti-APC (Ab-7) Mouse mAb (CC-1)

Synonyme(s) :

Anti-Adenomatus Polyposis Coli

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.45

Source biologique

mouse

Niveau de qualité

100

Clone

CC-1, monoclonal

Forme

liquid

Contient

≤0.1% sodium azide

Espèces réactives

human, mouse, rat

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

do not freeze

Technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (frozen sections): suitable

dilution

(Free-floating SectionsParaffin Sections)

Isotype

IgG2b

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Description générale

Recognizes APC in oligodendrocytes and astrocytes.

  • Antibody Target Gene Symbol: APC
  • Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC
  • Entrez Gene Name: adenomatous polyposis coli
  • Hu Entrez ID: 324 (Related Antibodies: ST1150, OP62, OP47L, OP44)
  • Mu Entrez ID: 11789
  • RatEntrez ID: 24205

Immunogène

a recombinant protein consisting of amino acids 1-226 of APC

Application

Frozen Sections (5 µg/ml) Immunofluorescence (5 µg/ml) Paraffin Sections (5 µg/ml, heat pre-treament required) Immunocytochemistry (see application references) Free Floating Sections (see application references)

Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody′s staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.

Conditionnement

Please refer to vial label for lot-specific concentration

Avertissement

Toxicity: Standard Handling

Forme physique

In 50 mM sodium phosphate buffer, 0.2% gelatin.

Remarque sur l'analyse

Negative control: MOPC 21 cells

Positive control: Purkinje cells or cerebellum tissue

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

J Groden et al.
Cell, 66(3), 589-600 (1991-08-09)
DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients. The intron-exon boundary sequences were defined for
L K Su et al.
Science (New York, N.Y.), 262(5140), 1734-1737 (1993-12-10)
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
Bhat, R.V., et al.
The Journal of Neuroscience, 14, 3059-3071 (1994)
L K Su et al.
Cancer research, 53(12), 2728-2731 (1993-06-15)
Germline mutations of the APC gene are responsible for familial adenomatous polyposis, an autosomal dominant inherited predisposition to colorectal tumors. Mutation of the APC gene is also an early, if not initiating, event for sporadic colorectal tumorigenesis. In both cases
K J Smith et al.
Cancer research, 54(14), 3672-3675 (1994-07-15)
The adenomatous polyposis coli protein (APC) is mutated in familial adenomatous polyposis patients as well as in sporadic colorectal tumors. In an attempt to further understand the function of APC, the subcellular localization of APC was examined. Wild-type and mutant
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