HTMP2MAG-54K

MILLIPLEX^® Human TIMP Magnetic Bead Panel 2 - Immunology Multiplex Assay

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in human cell/tissue culture supernatant samples.

• Code UNSPSC : 12161503
• eCl@ss : 32161000
• Nomenclature NACRES : NA.84

Propriétés

• Niveau de qualité: 200
• Espèces réactives: human
• Fabricant/nom de marque: Milliplex^®
• assay range: accuracy: 77-95%; standard curve range: 10-10,000 pg/mL; (TIMP-4); standard curve range: 20-20,000 pg/mL; (TIMP-1); standard curve range: 49-50,000 pg/mL; (TIMP-2); standard curve range: 98-100,000 pg/mL; (TIMP-3)
• Technique(s): multiplexing: suitable
• Méthode de détection: fluorometric (Luminex xMAP)
• Conditions d'expédition: wet ice

Description

Description générale

Tissue Inhibitors of Metalloproteinases (TIMPs) comprise a family of four inhibitors known as TIMP-1, TIMP-2, TIMP-3, and TIMP-4. Each member of the TIMP family has its own distinct profile of metalloproteinase inhibition. The matrix metalloproteinases (MMPs) are a family of zinc proteases involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, tissue and bone remodeling, wound healing, tissue morphogenesis, angiogenesis, and tumor metastasis. MMPs are also known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), cell proliferation, differentiation, and chemokine in/activation. The normal function of MMPs must be precisely regulated by their endogenous protein inhibitors, TIMPs . TIMPs inhibit MMPs by forming 1:1, non-covalent complexes with MMPs, thereby blocking access of substrates to the MMP catalytic site. Except for inhibition of active MMPs, TIMPs also exhibit several other biochemical and physiological/biological functions such as proMMP activation, cell growth promotion, matrix binding, inhibition of angiogenesis and the induction of apoptosis. Disruption of the MMP/TIMP balance can result in serious diseases such as arthritis, cardiovascular disorders, tumor growth and metastasis.

The MILLIPLEX^® Human TIMP Panel 2 Bead kit (TIMP-1, -2, -3, -4) has been designed for tissue/cell culture samples.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

Spécificité

Cross Reactivty
No significant cross-reactivity was observed among analytes in this panel.

Application

• Analytes: TIMP-1, TIMP-2, TIMP-3, TIMP-4
• Recommended Sample type: Tissue and cell culture supernatants
• Assay Run Time: One day or overnight
• Research Category: Inflammation & Immunology

Caractéristiques et avantages

Design your multiplex kit by choosing available analytes within this panel.

Stockage et stabilité

Recommended storage for kit components is 2 - 8°C.

Autres remarques

Sensitivity: Refer to kit protocol for sensitivities of individual analytes.

Informations légales

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302 + H312 + H332,H315,H317,H319,H335,H411
• Conseils de prudence: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 10 - Combustible liquids