528208

Plasminogen Activator Inhibitor-1, Mutant

from Recombinant, ≥95% (SDS-PAGE), liquid, PAI-1 inhibitor, Calbiochem^®

• Synonyme(s) : PAI-1, Mutant
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant, The Plasminogen Activator Inhibitor-1, Mutant, Human, Recombinant controls the biological activity of Plasminogen Activator. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
• Niveau de qualité: 100
• Pureté: ≥95% (SDS-PAGE)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles
• Conditions d'expédition: wet ice
• Température de stockage: −70°C

Description

Description générale

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 h at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1sec^-1).

Highly purified preparation of an altered form of human PAI-1 containing four mutated amino acids. Mutant PAI-1 is virtually unable to go latent and is stable at elevated temperature and pH for extended periods of time (t_½ = 145 hours at 37°C, pH 7.4). Inhibits uPA (K_i = 5.1 x 10⁶ M^-1 sec^-1) and tPA (K_i = 7.9 x 10⁵ M^-1 sec^-1).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Plasminogen Activator

Product does not compete with ATP.

Reversible: no

Target K_i: 5.1 x 106 M-1 sec-1, 7.9 x 105 M-1 sec-1 against uPA and tPA, respectively

Conditionnement

Please refer to vial label for lot-specific concentration.

Avertissement

Toxicity: Standard Handling (A)

Forme physique

In 100 mM NaCl, 50 mM sodium phosphate buffer, 1 mM EDTA, pH 6.6.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Autres remarques

Berkenpas, M.B., et al. 1995. EMBO J. 14, 2969.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable