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360512

Millipore

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Synonyme(s) :

Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate

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About This Item

Numéro CAS:
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.21

Niveau de qualité

Pureté

100.1% dry basis (titration)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Nombre d'agrégation

2.1

Couleur

white to off-white

pKa  

3.8

CMC

7.1 mM

Solubilité

water: 200 mg/mL
ethanol: soluble

Conditions d'expédition

ambient

Température de stockage

15-25°C

InChI

1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1

Clé InChI

OABYVIYXWMZFFJ-UHFFFAOYSA-M

Description générale

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.
Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pKa: 3.8).

Application

Glycocholic Acid, Sodium Salt- is suitable for use:

  • as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
  • in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
  • to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K1) to analyze its influence on the quality and stability of the mixed micelle systems

Actions biochimiques/physiologiques

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

Avertissement

Toxicity: Standard Handling (A)

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Tao Wang et al.
Food science & nutrition, 7(11), 3675-3680 (2019-11-26)
Classical mixed micelle systems make excellent parenteral drug carriers for lipophilic or poorly soluble drugs, but many formulations details are not fully understood and need further study. Thus, we constructed mixed micelle systems with lecithin and either glycocholic acid sodium
A Braun et al.
Pharmaceutical research, 14(10), 1472-1478 (1997-11-14)
During long-term treatment of various malignant or viral diseases with IFN-alpha up to 20% of patients develop anti-IFN-alpha antibodies for as yet unknown reasons. To address this issue, a mouse model using Balb/C mice was established and the relevance of
Feilong Sun et al.
Molecular pharmaceutics, 15(9), 3786-3795 (2018-08-01)
The aim of the study is to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations (based on egg phosphatidylcholine and glycocholic acid) of vitamin K, i.e., with and without DSPE-PEG2000. The uptake of vitamin
Cheng Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1072, 315-319 (2017-12-05)
A rapid, accurate and sensitive stable isotope dilution ultra performance liquidchromatography electrospray ionization tandem mass spectrometry (ID-UPLC-ESI-MS/MS) method for the determination of glycocholic acid (GCA) in human serum was developed and validated. Serum samples were spiked with D5-glycocholic acid and

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