1.00164

Acide borique

cryst., EMPROVE^® API, Ph. Eur., BP, NF

• Synonyme(s) : Orthoboric acid, Trihydroxidoboron
• Formule linéaire : H₃BO₃
• Numéro CAS: 10043-35-3
• Poids moléculaire : 61.83
• Numéro MDL: MFCD00011337
• Code UNSPSC : 12352106
• Numéro de classement CE : 233-139-2

Propriétés

• Agence: BP; NF; Ph. Eur.
• Niveau de qualité: 600
• Pression de vapeur: 2.6 mmHg ( 20 °C)
• Gamme de produits: EMPROVE^® API
• Pureté: 99.5-100.5% (alkalimetric)
• Forme: solid
• Puissance: 2660 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• pH: 3.8-4.8 (20 °C, 33 g/L in H₂O)
• Pf: 160 °C (dec.) (lit.)
• Solubilité: 49.2 g/L
• Densité: 1.489 g/cm³ at 23 °C
• Masse volumique apparente: 400‑600 kg/m³
• Traces d'anions: sulfate (SO₄^2-): ≤0.04%
• Traces de cations: As: ≤0.0001%; heavy metals (as Pb): ≤0.0015%
• Application(s): liquid formulation; ophthalmics; parenterals; pharmaceutical; semi-solid formulation
• Température de stockage: 2-25°C
• Chaîne SMILES: OB(O)O
• InChI: 1S/BH3O3/c2-1(3)4/h2-4H
• Clé InChI: KGBXLFKZBHKPEV-UHFFFAOYSA-N

Description

Description générale

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid as an active ingredient is used in ophthalmic drugs, as antiseptic for cuts and burns, as well as antibacterial for dermatological treatments such as acne and athlete foot. Boric acid Emprove^® API is manufactured according to ICH Q7 guidelines. A CEP and an US-DMF are available.

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H360FD
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 1B
• Code de la classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable