933570
NanoFabTx™- Maleimide Lipid Mix
for synthesis of maleimide-functionalized liposomes
Synonyme(s) :
Cholesterol, DSPC-PEG-Maleimide, HSPC
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About This Item
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.21
Produits recommandés
Niveau de qualité
Température de stockage
−20°C
Application
NanoFabTx™ Maleimide Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of maleimide-functionalized liposomes. Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with maleimide groups using extrusion and microfluidics are also included. The synthesized maleimide-functionalized liposomes enable facile conjugation of targeting groups like proteins, peptides, and other thiol-containing moieties onto the liposome surface for targeted drug delivery.
Caractéristiques et avantages
- A ready-to-use nanoformulation lipid blend for the synthesis of maleimide-functionalized liposomes
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Maleimide surface functionalization allows for targeting ligand and protein conjugation to enable targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Informations légales
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Hanmei Li et al.
Journal of biomedical nanotechnology, 17(12), 2382-2390 (2022-01-04)
Albumin, the most abundant protein in plasma, has been widely used in drug delivery studies. Here, we developed maleimide-functionalized liposomes (Mal-Lip) that can bind to endogenous albumin to improve the tumor targeting efficiency of liposomes. Transmission electron microscopy and gel
Mira Oswald et al.
International journal of pharmaceutics, 514(1), 93-102 (2016-11-20)
Numerous examples exist in the literature for the use of maleimide-thiol-reactions in the area of functionalized nanoparticles. Although the hydrolysis tendency of maleimides is well-known, qualitative and quantitative information on the stability and reactivity of maleimide groups during preparation and
Walhan Alshaer et al.
Bioconjugate chemistry, 26(7), 1307-1313 (2014-10-25)
CD44 receptor protein is found to be overexpressed by many tumors and is identified as one of the most common cancer stem cell surface markers including tumors affecting colon, breast, pancreas, and head and neck, making this an attractive receptor
Tianshu Li et al.
International journal of nanomedicine, 9, 2849-2861 (2014-06-19)
With a small amount of maleimide modification on the liposome surface, enhanced cellular uptake of liposomes and drug-delivery efficiency can be obtained both in vitro and in vivo. Herein, we describe the mechanisms underlying this enhanced cellular uptake. Suppression of
Tianshu Li et al.
International journal of nanomedicine, 8, 3855-3866 (2013-10-22)
Maleimide is a stable and easy-to-handle moiety that rapidly and covalently conjugates thiol groups of cysteine residues in proteins or peptides. Herein, we use maleimide to modify the surface of liposomes in order to obtain an advanced drug delivery system.
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