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  • Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory, and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators.

Journal of medicinal chemistry (2017-10-14)
Kelvine Chignen Possi, Mukandila Mulumba, Samy Omri, Yesica Garcia-Ramos, Houda Tahiri, Sylvain Chemtob, Huy Ong, William D Lubell
ABSTRACT

Azapeptide analogues of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Benzophenone hydrazone, 96%
Sigma-Aldrich
4-Fluorobenzyl bromide, 97%
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4-Iodobenzyl bromide, 95%
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2-Iodopropane, contains copper as stabilizer, 99%
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1-Iodopropane, 99%
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4-(Trifluoromethyl)benzyl bromide, 98%
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4-Chlorobenzyl bromide, 97%
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Benzyl bromide, reagent grade, 98%
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HBTU, ≥98.0% (T)