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  • Synthesis and characterization of polyanhydride for local BCNU delivery carriers.

Synthesis and characterization of polyanhydride for local BCNU delivery carriers.

Bio-medical materials and engineering (2005-05-25)
Moon Suk Kim, Kwang Su Seo, Ha Soo Seong, Sun Hang Cho, Hai Bang Lee, Keum Duck Hong, Sun Kyung Kim, Gilson Khang
ABSTRACT

p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a melt polycondensation process with a mixture of CPP and SA prepolymer. Copolymers of average molecular weight up to 110,000 g/mol were achieved. The crystallinity of poly(CPP-SA) copolymers was decreased by the addition of the CPP homopolymer segment to SA homopolymer. Poly(CPP-SA) copolymers gradually degraded for period of 10 days. No large difference of weight loss observed according to molecular weight variation of poly(CPP-SA) copolymers. BCNU release from wafers fabricated by poly(CPP-SA) showed a sustained release pattern with no initial burst and delay of drug release.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,3-Bis(4-carboxyphenoxy)propane, 97%
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