- The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.
The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.
Organic & biomolecular chemistry (2013-03-29)
Cynthia M Hong, Alexander V Statsyuk
PMID23536160
ABSTRACT
A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles.
MATERIALS