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Sphingosine-1-phosphate: an enigmatic signalling lipid.

Nature reviews. Molecular cell biology (2003-05-03)
Sarah Spiegel, Sheldon Milstien
ABSTRACT

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

MATERIALS
Product Number
Brand
Product Description

Avanti
16:0-d31-18:1 PI, 1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoinositol (ammonium salt), powder
Sigma-Aldrich
ChemiSCREEN Membrane Preparation Recombinant Human S1P5 Lysophospholipid Receptor, Human S1P5 / EDG8 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.