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Key Documents

AB15014

Sigma-Aldrich

Anti-Glycine Receptor α3 subunit Antibody

Chemicon®, from rabbit

Synonym(s):

glycine receptor alpha 3 subunit, glycine receptor, alpha 3, glycine receptor, alpha-3 polypeptide, ligand gated ion channel

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_006520.2

UniProt accession no.

O75311

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GLRA3(8001)

General description

Glycine receptor α3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family. Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals. The Glycine receptor is a neurotransmitter ligand-gated ion channel. GLRA3 is a pentamer that is composed of ligand binding alpha and structural beta subunits. When glycine binds to the receptor, chloride conductance increases which produces hyperpolarization. It is expressed in the hippocampus, olfactory bulb, and cerebellum. GLRA3 may be involved in human and murine neurological disorders.

Specificity

Rat (92%) homology.
This antibody recognizes Glycine Receptor α3 subunit.

Immunogen

This antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues surrounding the C-terminus of human Glycine Receptor α3 subunit.

Application

Anti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.
Immunohistochemistry Analysis: 1:100-500 dilution from a previous lot detected Glycine Receptor α3 subunit in mouse spinal cord and mouse eye tissue.

Target description

Approx. 48 kDa

Physical form

Format: Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Loss of Extrasynaptic Inhibitory Glycine Receptors in the Hippocampus of an AD Mouse Model Is Restored by Treatment with Artesunate.
Kuhse, et al.
International Journal of Molecular Sciences, 24 (2023)
Mario A Acuña et al.
The Journal of clinical investigation, 126(7), 2547-2560 (2016-06-09)
Diminished inhibitory neurotransmission in the superficial dorsal horn of the spinal cord is thought to contribute to chronic pain. In inflammatory pain, reductions in synaptic inhibition occur partially through prostaglandin E2- (PGE2-) and PKA-dependent phosphorylation of a specific subtype of

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