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Gastro retention using polymer cocoons.

Gastro retention using polymer cocoons.

Artificial cells, nanomedicine, and biotechnology (2014-08-01)

Julien Arnold, David Hunkeler

ABSTRACT

A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These "gastro cocoons" can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Acetone, for residue analysis, JIS 5000

Sigma-Aldrich

Acetone, for chromatography, ≥99.8%

Sigma-Aldrich

Acetone, suitable for HPLC

Sigma-Aldrich

Hydrochloric acid solution, 6 M

Sigma-Aldrich

Hydrochloric acid solution, 0.05 M

Sigma-Aldrich

Hydrochloric acid solution, 2 M

Sigma-Aldrich

Acetone, SAJ first grade, ≥99.0%

Sigma-Aldrich

Hydrochloric acid solution, 1 M

Sigma-Aldrich

Hydrochloric acid solution, 0.01 M

Sigma-Aldrich

Acetone, JIS special grade, ≥99.5%

Sigma-Aldrich

Acetone, ≥99.5%, for residue analysis

Sigma-Aldrich

Hydrochloric acid solution, 0.5 M

Sigma-Aldrich

Hydrochloric acid solution, 0.2 M

Sigma-Aldrich

Acetone, for residue analysis, ≥99.5%

Sigma-Aldrich

Hydrochloric acid, JIS special grade, 35.0-37.0%

Sigma-Aldrich

Hydrochloric acid solution, 0.02 M

Supelco

Acetone, Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

Chloromethane solution, 200 μg/mL in methanol, analytical standard

Sigma-Aldrich

Hydrochloric acid solution, 32 wt. % in H₂O, FCC

Sigma-Aldrich

Hydrogen chloride – ethanol solution, 0.1 M in ethanol

Sigma-Aldrich

Hydrochloric acid solution, 12 M

Sigma-Aldrich

Hydrochloric acid, SAJ first grade, 35.0-37.0%

Sigma-Aldrich

Hydrochloric acid solution, 1.0 N, BioReagent, suitable for cell culture

Supelco

Hydrochloric acid solution, volumetric, 0.1 M HCl (0.1N), endotoxin free

Sigma-Aldrich

Hydrochloric acid, 36.5-38.0%, BioReagent, for molecular biology

Supelco

Hydrogen chloride – 2-propanol solution, ~1.25 M HCl (T), for GC derivatization, LiChropur^™

Supelco

Acetone, analytical standard

Sigma-Aldrich

Chloromethane solution, 1.0 M in tert-butyl methyl ether, anhydrous

Supelco

Hydrogen chloride – ethanol solution, ~1.25 M HCl, for GC derivatization, LiChropur^™

Supelco

Hydrogen chloride – methanol solution, ~1.25 m HCl (T), for GC derivatization, LiChropur^™