C5174

4′-Chlorodiazepam

≥98% (TLC)

• Synonym(s): 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one, Ro 5-4864, Ro5-4864
• Empirical Formula (Hill Notation): C₁₆H₁₂Cl₂N₂O
• CAS Number: 14439-61-3
• Molecular Weight: 319.19
• Beilstein: 685202
• MDL number: MFCD00043406
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892765
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• solubility: 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• SMILES string: O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
• InChI: 1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
• InChI key: PUMYFTJOWAJIKF-UHFFFAOYSA-N
• Gene Information: rat ... Tspo(24230)

Description

Application

4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.

Biochem/physiol Actions

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves